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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

mast cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (1) Akt (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) Apoptosis (2) Aurora Kinase (1) Bacterial (1) Bcr-Abl (1) Biochemical Assay Reagents (1) Btk (1) c-Kit (4) Cathepsin (1) Cholinesterase (ChE) (1) Complement System (1) CRAC Channel (1) Endogenous Metabolite (6) FLT3 (1) Fluorescent Dye (3) GPR35 (1) Histamine Receptor (22) Influenza Virus (5) Interleukin Related (2) Isotope-Labeled Compounds (3) Leukotriene Receptor (2) Lipoxygenase (1) LPL Receptor (2) Mas-related G-protein-coupled Receptor (MRGPR) (3) Monoamine Oxidase (1) NF-κB (1) p38 MAPK (2) PDGFR (3) Phosphatase (3) Phospholipase (2) Prostaglandin Receptor (3) Protease Activated Receptor (PAR) (1) Proteasome (1) SARS-CoV (2) Ser/Thr Protease (1) SHP2 (1) STAT (1) Syk (2) TNF Receptor (3) VEGFR (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Endocrinology (16) Infection (9) Inflammation/Immunology (59) Metabolic Disease (1) Neurological Disease (7)

By Targets:

5-HT Receptor (1)

Adenosine Receptor (1)

Akt (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (1)

Apoptosis (2)

Aurora Kinase (1)

Bacterial (1)

Bcr-Abl (1)

Biochemical Assay Reagents (1)

Btk (1)

c-Kit (4)

Cathepsin (1)

Cholinesterase (ChE) (1)

Complement System (1)

CRAC Channel (1)

Endogenous Metabolite (6)

FLT3 (1)

Fluorescent Dye (3)

GPR35 (1)

Histamine Receptor (22)

Influenza Virus (5)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (2)

Lipoxygenase (1)

LPL Receptor (2)

Mas-related G-protein-coupled Receptor (MRGPR) (3)

Monoamine Oxidase (1)

NF-κB (1)

p38 MAPK (2)

PDGFR (3)

Phosphatase (3)

Phospholipase (2)

Prostaglandin Receptor (3)

Protease Activated Receptor (PAR) (1)

Proteasome (1)

SARS-CoV (2)

Ser/Thr Protease (1)

SHP2 (1)

STAT (1)

Syk (2)

TNF Receptor (3)

VEGFR (3)

By Research Areas:

Cancer (13)

Cardiovascular Disease (3)

Endocrinology (16)

Infection (9)

Inflammation/Immunology (59)

Metabolic Disease (1)

Neurological Disease (7)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115768

Compound 48/80 Poly-p-methoxyphenethylmethylamine	Others	Neurological Disease Cancer
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" **mast cell** activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .

HY-145892

MrgprX2 antagonist-6	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-6 (compound 9) is an anti-allergic agent. MrgprX2 antagonist-6 shows excellent anti-allergy effects and can inhibit mast cell degranulation .

HY-145893

MrgprX2 antagonist-7	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-7 (compound 10) is an anti-allergic agent. MrgprX2 antagonist-7 shows excellent anti-allergy effects and can inhibit mast cell degranulation .

HY-W062109

Olopatadine	Endogenous Metabolite Histamine Receptor	Inflammation/Immunology
Olopatadine is an orally active and selective histamine 1 (H₁) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis .

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-B0640A

Epinastine hydrochloride WAL801 hydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Epinastine hydrochloride (WAL801 hydrochloride) is an antihistamine and mast cell stabilizer. Epinastine hydrochloride is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine hydrochloride also inhibits IL-8 release and has an antiallergic action .

HY-B0640

Epinastine WAL801	Histamine Receptor	Inflammation/Immunology Endocrinology
Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action .

HY-12521

GSK-5498A 3 Publications Verification	CRAC Channel	Inflammation/Immunology
GSK-5498A is a selective CARC channel inhibitor (IC₅₀: 1 μM). GSK-5498A inhibits mediators release from mast cells and pro-inflammatory cytokines release from T cells. GSK-5498A can be used in the research of inflammatory disorders .

HY-105999

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell tryptase (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Others	Inflammation/Immunology
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-13508

JNJ-7777120	Histamine Receptor	Inflammation/Immunology
JNJ-7777120 is a potent and selective histamine H₄ receptor antagonist (K_i=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory .

HY-P99193

Enokizumab MEDI-528	Interleukin Related	Inflammation/Immunology
Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways .

HY-138961

ER-27319	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-108489

ER-27319 maleate	Syk	Inflammation/Immunology
ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases ^[1] ^[2].

HY-D1425

DCVJ 9-(2,2-Dicyanovinyl)julolidine	Fluorescent Dye	Others
DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells .

HY-P99371

Lirentelimab AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-B0157A

Ketotifen fumarate 1 Publications Verification HC 20511 fumarate	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N3007A

(E)-Naringenin chalcone	Others	Inflammation/Immunology
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-D0220A

Toluidine Blue (purity 36%) Toluidine Blue O (purity 36%)	Fluorescent Dye	Others
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-123532

JNJ10191584 VUF6002	Histamine Receptor	Neurological Disease
JNJ10191584 (VUF6002) is an orally active and selective histamine H₄ receptor antagonist with a K_i value of 26 nM. JNJ10191584 shows 540-fold selectivity to H₄ receptor over H₃ receptor with a K_i value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC₅₀ values of 530 nM and 138 nM, respectively .

HY-107558

JNJ10191584 maleate VUF6002 maleate	Histamine Receptor	Neurological Disease
JNJ10191584 (VUF6002) maleate (compound 40) is an orally active and selective histamine H₄ receptor antagonist with a K_i value of 26 nM. JNJ10191584 maleate shows 540-fold selectivity to H₄ receptor over the H₃ receptor with a K_i value of 14.1 μM. JNJ10191584 maleate inhibits chemotaxis of eosinophils and mast cells with IC₅₀ values of 530 nM and 138 nM, respectively .

HY-P1807

Mast Cell Degranulating Peptide HR-2	Histamine Receptor	Inflammation/Immunology
Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .

HY-N11691

Thapsigargicin Thapsigargicine	Others	Inflammation/Immunology
Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets .

HY-N8593

Undecane	TNF Receptor	Infection
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α ^[

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-N4207

Cnidicin

Others Others

Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .
HY-101810

Tazanolast

TO 188; Tazalest; Tazanol
Others Inflammation/Immunology

Tazanolast is a selective mast-cell-stabilizing agent, on ozone-induced airway hyperresponsiveness in guinea pigs.
HY-124252

5,8,11-Eicosatriynoic acid

ETI
Lipoxygenase Cancer

5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells .

Cnidicin	Others	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

Tazanolast TO 188; Tazalest; Tazanol	Others	Inflammation/Immunology
Tazanolast is a selective mast-cell-stabilizing agent, on ozone-induced airway hyperresponsiveness in guinea pigs.

5,8,11-Eicosatriynoic acid ETI	Lipoxygenase	Cancer
5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells .

HY-B0538A

Pemirolast potassium TWT-8152; BMY 26517	Histamine Receptor	Inflammation/Immunology Endocrinology
Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

HY-N8593S

Undecane-d24	TNF Receptor	Infection
Undecane-d₂₄ is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].

HY-P4580

Suc-Ala-Ala-Pro-Phe-SBzl	Proteasome	Others
Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .

HY-N2095

Atractylone Atractylon	Influenza Virus	Infection Inflammation/Immunology
Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions .

HY-16289

Lodoxamide tromethamine U-42585E	Histamine Receptor	Inflammation/Immunology Endocrinology
Lodoxamide tromethamine (U-42585E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

HY-100269

Chymase-IN-1

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM.

Chymase-IN-1
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM.

HY-W062109S

Olopatadine-d6	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology
Olopatadine-d₆ is the deuterium labeled Olopatadine[1]. Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[2][3].

HY-14270

Lodoxamide U-42585E free acid	Histamine Receptor	Inflammation/Immunology Endocrinology
Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

HY-105999B

APC 366 TFA

Others Others

APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases .

APC 366 TFA	Others	Others
APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases .

HY-N12295

Ciwujianoside D1	Others	Inflammation/Immunology
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells .

HY-B1619

Cromolyn Cromoglicic acid	Others	Inflammation/Immunology
Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis .

HY-148244

MS47134	Mas-related G-protein-coupled Receptor (MRGPR)	Others
MS47134 is a potent and selective MRGPRX4 agonist with an EC₅₀ value of 149 nM. MS47134 can be used for research of pain, itch and mast cell-mediated hypersensitivity .

HY-122161

JNJ-10311795 RWJ-355871	Cathepsin	Inflammation/Immunology
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (K_i = 38 nM) and mast cell chymase (K_i = 2.3 nM), exhibits noteworthy antiinflammatory activity .

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-N12254

Natsudaidain	p38 MAPK	Others
Natsudaidain is a kind of polymethoxyflavone. Natsudaidain can be isolated from Citrus plants. Natsudaidain inhibits tumor necrosis factor-α and cyclooxygenase-2 production n by suppressing p38 MAPK phosphorylation on mast cells .

HY-B0157AS

Ketotifen-d3 fumarate	Histamine Receptor SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology
Ketotifen-d₃ (fumarate) is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks[1][2].

HY-P99462

Barzolvolimab CDX 0159	c-Kit	Inflammation/Immunology
Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-B1404

Nylidrin hydrochloride Buphenine hydrochloride
Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices.

HY-B1619S

Cromoglicic acid-d5 Cromoglicic acid-d₅	Isotope-Labeled Compounds	Inflammation/Immunology
Cromoglicic acid-d₅ is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Endogenous Metabolite	Inflammation/Immunology
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

HY-110013

Terreic acid	Btk Antibiotic	Infection Inflammation/Immunology
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-19839

Ansamitocin P 3' Antibiotic C 15003P3'; Maytansinol butyrate
Ansamitocin P 3' (Antibiotic C 15003P3') is an anti-tumor antibiotic. Ansamitocin P 3' prolongs the survival of mice with leukemia P388, melanoma B16, leukemia L1210, sarcoma 180, Ehrlich carcinoma and mast cell tumor P815 .

Cat. No.	Product Name	Target	Research Area

HY-P5717

Peptide 12d	Peptides	Infection
Peptide 12d is an antimicrobial peptide isolated from the venom of wasp. Peptide 12d mediates antimicrobial response by stimulating mast cell degranulation .

HY-P1807

Mast Cell Degranulating Peptide HR-2	Histamine Receptor	Inflammation/Immunology
Mast Cell Degranulating Peptide HR-2, a 14-membered linear peptide isolated from the venom of the giant hornet Vespa orientalis, is capable of degranulating mast cells and thus initiating histamine release .

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-P2442

Bombolitin V

Peptides Others

Bombolitin V is a potent antimicrobial peptide with an ED ⁵⁰ value of 2 micrograms/ml in causing mast cell degranulation .

HY-P4580

Suc-Ala-Ala-Pro-Phe-SBzl	Proteasome	Others
Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .

HY-P1987

Mast cell degranulating peptide (28-49)	Peptides	Neurological Disease
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .

HY-P5727

HR1	Peptides	Infection
HR1 is a mastoid protease. HR1 can increase the permeability of human erythrocyte membrane. HR1 can induce cytoplasmic membrane permeation in bacteria and mast cells .

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-P3837

Xenopsin-Related Peptide 2 XP-2	Peptides	Metabolic Disease
Xenopsin-Related Peptide 2 (XP-2) is an avian counterpart to amphibian Xenopsin (HY-P0253). Xenopsin-Related Peptide 2 displays abilities to release histamine from isolated rat mast cells and is as effective as synthetic Bradykinin (HY-P0206) .

HY-106178

PMX-53 3 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Natural Products Polygonum chinense Linn. Polygonaceae Source classification Plants	Others
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-B0157A

Ketotifen fumarate 1 Publications Verification HC 20511 fumarate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-W062109

Olopatadine	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Histamine Receptor
Olopatadine is an orally active and selective histamine 1 (H₁) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis .

HY-122295

Dehydroleucodine	Structural Classification other families Artemisia douglasiana Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N3007A

(E)-Naringenin chalcone	Structural Classification Phenols Polyphenols Lycopersicon esculentum Miller Plants Solanaceae	Others
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-N11691

Thapsigargicin Thapsigargicine	Structural Classification Terpenoids Source classification Diterpenoids Plants Umbelliferae	Others
Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets .

HY-N8593

Undecane	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	TNF Receptor
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α ^[

HY-N4207

Cnidicin	Classification of Application Fields Source classification Other Diseases Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields Echinacea angustifolia DC.	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N2095

Atractylone Atractylon	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields Erythrina sigmoidea Hua	Influenza Virus
Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions .

HY-N12295

Ciwujianoside D1	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells .

HY-P1987

Mast cell degranulating peptide (28-49)	Natural Products Animals Source classification	Others
Mast cell degranulating peptide (28-49) is a depolarizing agent from bee venom, it can raise the content of cGMP level in mouse cerebellar slices .

HY-N12254

Natsudaidain	Structural Classification Flavonols Flavonoids Source classification Rutaceae Citrus japonica Thunb. Plants	p38 MAPK
Natsudaidain is a kind of polymethoxyflavone. Natsudaidain can be isolated from Citrus plants. Natsudaidain inhibits tumor necrosis factor-α and cyclooxygenase-2 production n by suppressing p38 MAPK phosphorylation on mast cells .

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Pelargonium hortorum Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Geraniaceae	Endogenous Metabolite
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

HY-N3421

Koaburaside	Structural Classification Eucommia ulmoides Oliver Source classification Eucommiaceae Plants Saccharides Monosaccharides	Interleukin Related TNF Receptor Influenza Virus
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-N10182

Spinacetin	Phyllodium pulchellum (L.) Desv. Structural Classification Flavonols Flavonoids Source classification Plants Compositae	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-N4126

6-Demethoxytangeretin	Flavonoids other families Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Cancer	Anaplastic lymphoma kinase (ALK)
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways . 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons .

HY-N0631

Cornuside 1 Publications Verification	Structural Classification Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	p38 MAPK NF-κB
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases .

HY-103183

CV1808 2-Phenylaminoadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Adenosine Receptor Endogenous Metabolite
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-N7292

Bakkenolide B	Other Terpenoids Classification of Application Fields Terpenoids Source classification Plants Compositae Disease Research Fields Inflammation/Immunology Piptadenia Benth.	Others
Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma .

HY-Y0320

Dimethyl sulfoxide Maximum Cited Publications 89 Publications Verification DMSO	Microorganisms Source classification	Bacterial Cholinesterase (ChE)
Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties . MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

HY-114203

Eckol	Eisenia bicyclis Structural Classification other families Source classification Phenols Polyphenols Plants	Monoamine Oxidase Influenza Virus
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC₅₀s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .

Cat. No.	Product Name	Chemical Structure